This is an interesting, though anti-liberty, this article about the secessionist movements in Europe.
I think that the EU will eventually break up. I have been thinking this since at least 2009. I think that the European central bank will continue to inflate to the very end to try to keep the system together but it will still break up in the end whether the it is from secessionist movements or economic reality.
I think there will also eventually be a push from the grass roots level in many of the American States to break away as well if the Federal Reserve does not let off the monetary gas and leads the U.S. into a hyper inflation scenario.